New Zealand


Mastalone is a broad spectrum antibiotic for the control of mastitis in lactating cattle. Mastalone is effective against the bacteria commonly isolated during lactation ie. Staphylococci (including penicillin resistant strains), Streptococcus uberis, Streptococcus dysgalactiae and Streptococcus agalactiae and Escherichia coli.

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  • Mastalone is indicated for local treatment of acute and chronic mastitis in dairy cattle caused by, or associated with, micro-organisms susceptible to the antibiotics contained in this formulation.  Mastalone is also indicated for the treatment of otitis externa, bacterial dermatitis, superficial wounds and abscesses in dogs and cats.

    Oxytetracycline acts within the bacterial ribosomes, inhibiting protein synthesis by binding specifically to the 30S ribosomes, thus preventing the addition of amino acids to peptide chains.  In vitro, oxytetracycline is bacteriostatic; however, at higher concentrations it is bactericidal.

  • Broad spectrum - Mastalone is a broad spectrum antibiotic for severe mastitis, hard to cure infections or when causative bacteria are unknown.

    Efficacy - Mastalone is ideally suited for treatment of acute clinical mastitis in lactating cattle. The addition of prednisolone makes it ideal for the treatment of peracute and acute mastitis characterised by swelling of the quarter.

    Low resistance - The antibiotics in Mastalone have different sites of action making their anti-bacterial activities complementary. The combination of antibiotics demonstrated lower levels of bacterial resistance than to any of the single antibiotics alone. In vitro, synergism has been demonstrated between neomycin and oxytetracycline and between oxytetracycline and oleandomycin. Bacteriological cure rates of 75%1 have been demonstrated.

  • Mastalone contains 200mg oxytetracycline HCl, 100mg oleandomycin base (as phosphate), 100mg neomycin (as sulphate) and 5mg prednisolone in a yellow, oil-based solution.

    Mastalone is available in packs of 20 x 10mL syringes.


    Mastitis: The entire contents (10mL) of 1 syringe should be infused into each affected quarter immediately after milking. Ensure that the affected quarters are thoroughly stripped out before treatment. Treatment should be repeated at 24-hour intervals for 3 days.

    Otitis Externa/Dermatitis: In treating otitis externa it is suggested that the cerumen and debris should first be removed. Sufficient product should be introduced to coat the ear canal. Treatment should be repeated at 24-hour intervals.


    Meat: Cows producing meat and offal for human consumption must not be sold for slaughter either during treatment or within 30 days of the last treatment.

    Milk: Milk intended for sale for human consumption must be discarded during treatment and for not less than 8 milkings or approximately 96 hours following the last treatment. Milk taken from cows during treatment and the withholding period should not be fed to bobby calves.

    Store below 25°C (air conditioning).Dispose of empty syringes by wrapping with paper and putting in garbage.

  • Mastalone is relatively non-toxic and chronic tests have failed to produce any significant toxic effect in laboratory animals.

    Prolonged therapy may result in super-infection with fungi.

    This material may cause sensitisation from prolonged skin contact. Avoid skin contact.

  • Zoetis Animal Health New Zealand Limited. Level 5, 8 Mahuhu Crescent, Auckland 1010, New Zealand. Tel: 0800 650 277, Fax: 0800 628 629. MASTALONE is a registered trade mark of Zoetis Inc. or its subsidiaries. ACVM Registration No. A0829. RVM; Available only under Veterinary Authorisation.


    1. Zoetis Animal Health Trial Report No. 1530-12-78-060
  • For technical enquiries please phone Zoetis Technical Services on 0800 650 277.