Lutalyse

Lutalyse is approved for use in cattle, horses and pigs. For synchronising oestrus in cycling cattle and treatment of suboestrus in horses. To induce abortion in cattle and horses. Induction of parturition in cattle and pigs. To control breeding in cattle.

Dinoprost trometamol is a naturally-occurring prostaglandin. The exact method by which PGF2α is luteolytic is unknown. Some hypotheses advanced include: that it acts by altering blood flow (substrate deprivation or end-product inhibition) either to the ovary or most probably to the corpus luteum; another is that it acts by altering steroidogenesis, either directly or through blocking precursor availability; a third is that it interferes with the binding of gonadotrophins by luteal cells.

Nil withhold – Lutalyse has a nil milk and meat withhold for cattle, horses and pigs.

Lutalyse is a white, crystalline, water-soluble powder containing 5mg/mL dinoprost (dinoprost trometamol).

Lutalyse is available in vials of 30mL and 100mL.

Store at room temperature (15–30°C).

Cattle: Administer 5mL (25mg) intramuscularly in anterior half of the neck. Abortion can be successfully induced from 5 to 150 days of gestation. After 150 days of gestation the addition of 25mg dexamethasone is recommended, to assist efficacy.

Horses: Administer 1mL (5mg) intramuscularly. At this level abortion occurs at days 5–35 of gestation. After 35 days gestation, give repeated daily injections until abortion occurs.

Pigs: Administer 2mL (10mg) intramuscularly behind the ear to induce parturition.

Withholding Periods:

Milk: Nil.

Meat: Cattle, Pigs and Horses: Nil.

Do not administer to pregnant animals unless abortion is intended. Induced parturition may precipitate dystocia, foetal death, retained placenta or metritis. Induction of parturition in swine earlier than 72 hours prior to the predicted farrowing date may result in piglet mortality. Do not administer intravenously.

25mg/day for 10 days in cattle gave no effect on haematology or clinical chemistry. There was an increase in heart rate and rectal temperature but no gross lesions at necropsy. At luteolytic doses it did not impair fertility of cattle and had no effect on progeny. In adult mares, 400–800mg/day for 8 days gave reduced sensitivity to pain; locomotor in-coordination; hypergastromotility; sweating; hyperthermia; laboured respiration; elevated cholesterol, glucose, bilirubin, haemoglobin and erythrocytes, but reduced eosinophils. No adverse effects were sustained.

Cattle: Sometimes salivation and increased rectal temperature may occur.

Horses: May sweat and have decreased rectal temperature, increased heart and respiratory rates, abdominal pain and in-coordination. These symptoms appear within 15 minutes and disappear within 1 hour.

Pigs: Increased body temperature and respiration, salivation, restlessness, defecation and urination in pregnant sows.

Not for human use. Keep away from pregnant women, asthmatics or persons with respiratory problems. If spilt on skin, wash off immediately with soap and water.

Zoetis Animal Health New Zealand Limited. Level 5, 8 Mahuhu Crescent, Auckland 1010, New Zealand. Tel: 0800 650 277, Fax: 0800 628 629. LUTALYSE is a registered trade mark of Zoetis Inc. or its subsidiaries. ACVM Registration No. A3231. RVM; Available only under Veterinary Authorisation.

For technical enquiries please phone Zoetis Technical Services on 0800 650 277.

• Zoetis Safety Data Sheets
• Label: http://www.foodsafety.govt.nz/