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Convenia

Convenia (cefovecin) is a long acting broad spectrum fourth group cephalosporin for subcutaneous injection in dogs and cats. Convenia is the only antibiotic to provide an assured course of treatment with a single injection lasting 14 days across a broad range of skin and soft tissue infections.

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  • Approved uses/Indications

    Convenia is approved for use in cats and dogs for the treatment of serious infections that are susceptible to β-lactam antibiotics.

    • Dogs: For the treatment of skin and soft tissue infections including pyoderma, wounds and abscesses associated with Staphylococcus intermedius, β-haemolytic Streptococci, Escherichia coli and/orPasteurella multocida.

    For the treatment of urinary infections associated with Escherichia coli and/orProteues spp.

    • Cats: For the treatment of skin and soft tissue abscesses, and wounds associated with Pasteurella multocida,Fusobacteriumspp.,Bacteroidesspp.,Prevotella oralis, β-haemolytic Streptococci and/or Staphylococcus intermedius.

    For the treatment of urinary infections associated with Escherichia coli

    Convenia is a fourth group cephalosporin with a broad spectrum of activity against Gram-positive and Gram-negative bacteria including β-lactamase producing strains. The action of cefovecin results from the inhibition of bacterial cell wall synthesis; cefovecin has bactericidal activity.

  • Key Features
    • Convenia’s unique pharmacokinetic profile represents a profound advance in companion animal antibiotic therapy.
    • Convenia is the only antibiotic to provide an assured course of treatment with a single injection lasting 14 days across a broad range of skin and soft tissue infections.
    • Convenia has an extended spectrum of bactericidal activity against Gram+ and Gram- anerobes and anaerobes1 including many penicillinase-producing strains.
    • Convenia has an excellent safety profile, typical of β-lactam antibiotics.
    • Convenia is well tolerated; it is a low volume (1mL/10kg) non-depot aqueous solution that is rapidly and completely absorbed from the sit of the injection. Even at 22.5 times the label dose, no significant adverse reasctions were observed2,3.
  • Packaging

    Convenia is available as a multi-use vial containing 852 mg of cefovecin (sodium salt) as sterile powder.

    Convenia contains 80 mg of cefovecin per mL (as sodium salt) on reconstitution with 10mL sterile water for injection.

  • Dosage & Administration

    Aseptically reconstitute Convenia with 10ml of diluent provided. Shake the vial until the powder is seen to have fully dissolved.

    Dogs and Cats:Administer 8 mg cefovecin per kg bodyweight (1mL/10 kg body weight).

    Animal body weight (kg)

    Dose volume (mL)

    2.5

    0.25

    5

    0.5

    10

    1.0

    20

    2.0

    40

    4.0

    60

    6.0

     

    For skin and soft tissue infections in cats and dogs a single injection is recommended. In dogs, subject to clinical response, this may be repeated three times at 14 day intervals (total of 4 doses). In cats, a single additional dose may be administered 14 days after the first (total of 2 doses).

    For urinary tract infections in cats and dogs, a single injection is recommended.

    Before reconstitution: Store in a refrigerator (2°C to 8°C). Do not freeze. Store in the original package in order to protect from light.

    After reconstitution: Store in a refrigerator (2°C to 8°C). Do not freeze. Store in the original package in order to protect from light. Shelf-life after reconstitution is 56 days providing aseptic handling techniques are used.

  • Precautions

    Do not use in the case of hypersensitivity to cephalosporin or penicillin antibiotics. Do not use in small herbivores (including guinea pigs and rabbits). Do not use in dogs and cats less than 8 weeks old.

    Cefovecin may persist in the body for approximately 4 to 5 weeks; therefore, adverse event monitoring should be carried out for a similar amount of time.

    The safety of Convenia in dogs and cats has not been established during pregnancy and lactation. The safety of Convenia has not been assessed in animals suffering form severe renal dysfunction.

    Convenia must not be mixed with other veterinary medicinal products in the same syringe.

    Β-lactam antibiotics, including penicillins and cephalosporins, may cause sensitisation following dermal or parenteral contact and, in previously sensitised (allergic) individuals, adverse reactions may result from such exposure. Individuals known to be sensitised to this class of compounds should be aware of the potential for serious allergic reactions when handling the drug. This product contains methyl parahydroxybenzoate (E2118) and propyl parahydroxybenzoate (E216). Hypersensitivity reactions to parabens have been reported. Avoid direct contact.

    Prudent Use: It is prudent to reserve third generation cephalosporins for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials including first generation cephalosporins. Use of the product should be based on susceptibility testing and take into account official, and local, antimicrobial policies. Indiscriminate use of CONVENIA could contribute to the development of antibiotic resistance.

  • Mandatories

    Zoetis Animal Health New Zealand Limited. Level 5, 8 Mahuhu Crescent, Auckland 1010, New Zealand. Tel: 0800 650 277, Fax: 0800 628 629. CONVENIA is a registered trade mark of Zoetis Inc. or its subsidiaries. ACVM Registration No. A10032. RVM; Available only under Veterinary Authorisation.

    References:

    • NZ Convenia ACVM approved label
    • Zoetis Study 1461N-60-00-419
    • Zoetis Study 1481N-60-99-216
  • Contact Information

    For technical enquiries please phone Zoetis Technical Services on 0800 650 277.

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