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This vaccine is prepared from formalin killed cultures of Leptospira borgpetersenii serovar Hardjo bovis and Leptospira interrogans serovar Pomona, an antigenically balanced mixture of ultra filtered antigens of Clostridium perfringens type D, Clostridium tetani, Clostridium septicum and Clostridium novyi type B and a purified formol culture of Clostridium chauvoei.
For the routine immunisation of cattle for the prevention of enterotoxaemia (pulpy kidney disease), tetanus, black disease, malignant oedema (blackleg-like disease), blackleg and leptospirosis caused by L. hardjo and L. pomona.
For the prevention of urinary shedding of the named leptospires in cattle when used prior to natural exposure and to prevent the risk of human leptospiral infection associated with the shedding of the named leptospires in the urine and from the reproductive tract of cattle.
For the protection against reproductive losses in cattle by prevention of reproductive tract colonisation and placental and foetal infection with L. hardjo.
Effective prevention: Ultravac 7in1 prevents reproductive tract colonisation and foetal infection. Ultravac 7in1 vaccine is effective in the presence of MDA. A 1991 study showed calves that were first vaccinated as early as 4 weeks of age, were fully protected against renal colonisation and urinary shedding when challenged with L. Hardjo 6 months later1.
Safe and Efficacious: Ultravac 7in1 has been fully tested for sterility and safety before issue. Trials using this vaccine strain of L. Hardjo have demonstrated high efficacy in the prevention of infection and shedding when vaccinated cattle are challenged1.
Long lasting: Ultravac 7in1 has a duration of immunity of at least 12 months.
Unique label claims:
Ultravac 7in1 is presented in 100mL, 250mL and 500mL packs.
The dose in all situations is 2.5mL injected subcutaneously (just under the skin) high on neck behind the ear.
Herd vaccination: To begin a herd vaccination programme, all animals must be vaccinated and a second dose given 4–6 weeks later. An annual booster dose of the vaccine must be given. This programme is applicable to dairy and beef herds.
Vaccination of calves: Early vaccination of calves is advisable to protect against acute leptospirosis ("Redwater"). Early vaccination is also advised to minimise the risk of animals becoming infected with leptospirosis and to prevent urinary shedding. Ultravac 7in1 has been shown to be efficacious in the presence of maternal antibody. Calves may therefore receive their first vaccination from 1 month of age1. Lasting efficacy, preventing urinary shedding of leptospires, can be expected if vaccination is commenced before first exposure. Calves infected prior to vaccination may become carriers and may continue to shed leptospires in the urine for several months, despite subsequent vaccination. Two doses should be given, 4–6 weeks apart. Calves less than 3 months of age at the time of the second vaccination should receive a single booster dose 6 months later. This booster may be used to align calves vaccinated “out of season” (i.e. when young, or in a town supply herd) with the annual herd booster.
Introduced stock: In the absence of a known history of vaccination, dose twice at a 4–6 week interval.
Development of immunity: Detectable levels of antibody develop 10 to 14 days after the second vaccination. The second dose of vaccine, 4 to 6 weeks after the first, is essential before a high level of immunity can develop. In cattle the L. borgpetersenii serovar hardjo component of Ultravac 7in1 has been demonstrated to induce a strong, sustained cell-mediated immune response against L. hardjo. A cell-mediated immune response is associated with protection against L. hardjo2,3.
Booster doses: To maintain immunity, all animals in the herd, including steers and bulls, should be revaccinated annually against leptospirosis. Breeding females should be given their annual booster about a month before calving or at drying off, which will also pass on temporary immunity to their offspring in their colostrum or “first milk”. A booster dose of a suitable multicomponent vaccine given 12 months after the two basic doses of vaccine should confer lifelong immunity against tetanus and blackleg. To maintain effective immunity against black disease, annual booster doses of a suitable multicomponent vaccine should be given.
The two basic doses of Ultravac 7in1 should provide effective immunity against enterotoxaemia for three months. Booster doses are therefore necessary to maintain immunity against enterotoxaemia in cattle and should be given at appropriate intervals according to local and seasonal conditions.
Some swelling usually develops at the site of vaccination, and may last for some months before gradually subsiding. On rare occasions, allergic shock reactions may occur. In these cases adrenaline should be administered.
Correct vaccination procedure is important. It is important that the vaccine is properly mixed before and during use. Shake the vaccine container at regular intervals to sustain mixing.
This vaccine has been fully tested for sterility and safety before issue but it must be stressed that the correct vaccination procedure in the field is equally important if secondary infection is to be prevented. Very occasionally pathogenic organisms lying dormant in the animal’s tissues are activated at the time of vaccination. This may lead to losses of stock but fortunately is of rare occurrence. As the above factors are beyond the control of the manufacturer except to the extent of any liability imposed by statute law without right of exclusion, cannot accept responsibility for any disability or loss of stock following vaccination in respect of failure to use the correct vaccination procedure described on the label or disability or loss to any animal caused by the product.
Black disease occurs as a sequel to liver fluke infestation and deaths can result from this cause also. The use of Ultravac 7in1 to prevent black disease does not protect against losses caused by liver fluke.
Withholding periods: Nil
Store at 2–8°C (refrigerate; do not freeze. Protect from light. This product can be stored and used for up to 30 days after first opening. Leptospirosis is an infectious disease that can affect all domestic and wild animals. It is transmissible to man and is probably the most widespread zoonosis in the world.
New Zealand Limited. Level 5, 8 Mahuhu Crescent, Auckland 1010, New Zealand. Tel: 0800 650 277, Fax: 0800 628 629. ULTRAVAC is a registered trade mark of Pfizer Inc. or its subsidiaries. ACVM Registration No. A6935: RVM; Available only under Veterinary Authorisation. ACVM Registration No’s A3585, A6926 & A10191: Unrestricted.
References:
For technical enquiries please phone Zoetis Technical Services on 0800 650 277.
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